Background, mostly from Wikipedia:
Directed by Jean de Limur, the story is based on the 1927 play of the same name by W. Somerset Maugham. It was inspired by a real-life scandal involving the wife of the headmaster of a school in Kuala Lumpur who was convicted in a murder trial after shooting dead a male friend in April 1911.
The lead character, Jeanne Eagles, was a former Ziegfeld Girl and went on to greater fame on Broadway and in the emerging medium of sound films. She posthumously was nominated for the Academy Award for Best Actress for her 1929 role in The Letter after dying suddenly that year at the age of 39. That nomination was the first posthumous Oscar consideration for any actor, male or female.
In September 1929, Eagels underwent eye surgery at St. Luke’s Hospital in New York City. At the time, she was also suffering from breathing problems and neuritis. After a ten-day stay, she returned to her apartment on Park Avenue. On October 3, 1929, Eagels and her secretary walked to the Park Avenue Hospital where Eagels had an appointment. While talking to the doctor, she began having convulsions and died shortly thereafter.[12] The assistant chief medical examiner who performed Eagels’ autopsy concluded that she died of “alcoholic psychosis”.